Complex regulation of gene expression in mammals has evolved from simpler eukaryotic
systems, yet the mechanistic features of this evolution remain elusive. Here, we compared …

Understanding the complex network that regulates transcription elongation requires the
quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory …

SPT6 is a conserved elongation factor that is associated with phosphorylated RNA
polymerase II (RNAPII) during transcription. Recent transcriptome analysis in yeast mutants …

Transcription can be controlled by regulating either the initiation or elongation of RNA
chains. Recent studies highlight the importance of an elongation regulator, Spt5, in …

Several eukaryotic transcription factors have been shown to modulate the elongation rate of
RNA polymerase II (Pol II) on naked or chromatin‐reconstituted templates in vitro. However …

Transcription elongation by RNA polymerase II was often considered an invariant non-
regulated process. However, genome-wide studies have shown that transcriptional pausing …

Transcription initiation entails chromatin opening followed by pre-initiation complex
formation and RNA polymerase II recruitment. Subsequent polymerase elongation requires …

To physically characterize the web of interactions connecting the Saccharomyces cerevisiae
proteins suspected to be RNA polymerase II (RNAPII) elongation factors, subunits of …

More than a decade ago, the purification of the form of the RNA polymerase II (PolII)
engaged in elongation led to the discovery of an associated, multi-subunit (Elp1-6) complex …

A previous study of histone H3 in Saccharomyces cerevisiae identified a mutant with a
single amino acid change, leucine 61 to tryptophan, that confers several transcriptional …