Platelet-activating factor is a phospholipid with diverse potent physiological effects. Its
actions are achieved at concentrations as low as IO-'” M in some systems and almost always …

I. Introduction In the autumn of 1979, three independent laboratories (1–3) described the
chemical structure of a new subclass of phospholipids that possessed biologic properties …

The ether phospholipid platelet-activating factor (PAF) has been generally assumed to be
released into the extracellular environment by the cells of origin, whereupon it effects its well …

Platelet-activating factor (PAF) is the common name given to lO-alkyl-2-acetyl-sn-glycero-3-
phospho-choline (Fig. la: also. see refs 14). a biologically active phospholipid. It transmits …

Platelet-activating factor (PAF, 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a potent
biological mediator that exerts its effects in a variety of cells and tissues (1-3). This …

Due to multiple molecular species of platelet-activating factor (PAF) and the existence of
high affinity binding sites in a variety of cells and tissues, possible existence of PAF receptor …

Abstract Platelet-activating factor (PAF), but not its deacetylated and biologically inactive
metabolite lyso-PAF, in a dose dependent-manner (0.1 to 10 nM), induces human …

Human polymorphonuclear neutrophils rapidly incorporated radiolabeled platelet-activating
factor, 1-O-[hexadecyl-9, 10-3H2]-2-acetyl-sn-glycero-3-phosphocholine ([3H] PAF), and …

A glyceryl ether containing phosphoglyceride, 1-O-alkyl-2-acetyl-sn-glyceryl-3-
phosphorylcholine (Ac-GEPC), has been shown to have a biological activity …

Platelet activating factor (PAF) research, could be divided into three periods. The first, which
could be named the 'pioneer period', started in the sixties, when a reaction involving …