Glia maturation factor induces interleukin-33 release from astrocytes: implications for neurodegenerative diseases
D Kempuraj, MM Khan, R Thangavel, Z Xiong… - Journal of Neuroimmune …, 2013 - Springer
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD)
and Multiple sclerosis (MS) involve activation of glial cells and release of inflammatory …
and Multiple sclerosis (MS) involve activation of glial cells and release of inflammatory …
Treatment with the CSF1R antagonist GW2580, sensitizes microglia to reactive oxygen species
K Soto-Diaz, M Vailati-Riboni, AY Louie… - Frontiers in …, 2021 - frontiersin.org
Microglia activation and proliferation are hallmarks of many neurodegenerative disorders
and may contribute to disease pathogenesis. Neurons actively regulate microglia survival …
and may contribute to disease pathogenesis. Neurons actively regulate microglia survival …
Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells
S Wei, S Nandi, V Chitu, YG Yeung… - Journal of leukocyte …, 2010 - academic.oup.com
CSF-1 and the novel CSF-1 receptor ligand, IL-34, possess similar CSF-1R-mediated
activities, but differ in their spatio-temporal expression, permitting complementary CSF-1 …
activities, but differ in their spatio-temporal expression, permitting complementary CSF-1 …
Function of CSF1 and IL34 in macrophage homeostasis, inflammation, and cancer
WY Lin, D Xu, CD Austin, P Caplazi, K Senger… - Frontiers in …, 2019 - frontiersin.org
Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to
regulate macrophage differentiation. Studies in IL34-or CSF1-deficient mice have revealed …
regulate macrophage differentiation. Studies in IL34-or CSF1-deficient mice have revealed …
CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation
D Hwang, MS Seyedsadr… - Proceedings of the …, 2022 - National Acad Sciences
The receptor for colony stimulating factor 1 (CSF-1R) is important for the survival and
function of myeloid cells that mediate pathology during experimental autoimmune …
function of myeloid cells that mediate pathology during experimental autoimmune …
Microglia: same same, but different
K Kierdorf, M Prinz - 2019 - rupress.org
Microglial identity in the central nervous system (CNS) is dependent on colony stimulating
factor 1 receptor (CSF-1R) signaling and its ligands IL-34 and colony stimulating factor 1 …
factor 1 receptor (CSF-1R) signaling and its ligands IL-34 and colony stimulating factor 1 …
CSF-1 signaling in macrophages: pleiotrophy through phosphotyrosine-based signaling pathways
KA Mouchemore, FJ Pixley - Critical reviews in clinical laboratory …, 2012 - Taylor & Francis
Colony stimulating factor-1 (CSF-1, also known as macrophage-colony stimulating factor, M-
CSF) has long been known as the primary growth factor regulating survival, proliferation and …
CSF) has long been known as the primary growth factor regulating survival, proliferation and …
Inhibition of IL-34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in a model of chronic neurodegeneration
J Obst, E Simon, M Martin-Estebane, E Pipi… - Frontiers in …, 2020 - frontiersin.org
The proliferation and activation of microglia, the resident macrophages in the brain, is a
hallmark of many neurodegenerative diseases such as Alzheimer's disease (AD) and prion …
hallmark of many neurodegenerative diseases such as Alzheimer's disease (AD) and prion …
Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34
Interleukin-34 (IL-34) is highly expressed in brain. IL-34 signaling via its cognate receptor,
colony-stimulating factor-1 receptor (CSF-1R), is required for the development of microglia …
colony-stimulating factor-1 receptor (CSF-1R), is required for the development of microglia …
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
The differentiation of bone marrow–derived progenitor cells into monocytes, tissue
macrophages and some dendritic cell (DC) subtypes requires the growth factor CSF1 and its …
macrophages and some dendritic cell (DC) subtypes requires the growth factor CSF1 and its …