CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages
Colony-stimulating factor 1 receptor (CSF1R) inhibition has been proposed as a method for
microglia depletion, with the assumption that it does not affect peripheral immune cells …
microglia depletion, with the assumption that it does not affect peripheral immune cells …
Regulation of granulocyte colony-stimulating factor gene expression by interleukin-17
XY Cai, CP Gommoll Jr, L Justice, SK Narula, JS Fine - Immunology Letters, 1998 - Elsevier
Interleukin-17 (IL-17) has been previously reported to induce stromal cells to produce a
number of hematopoietic and proinflammatory cytokines, including granulocyte colony …
number of hematopoietic and proinflammatory cytokines, including granulocyte colony …
IL-34 and M-CSF form a novel heteromeric cytokine and regulate the M-CSF receptor activation and localization
AI Ségaliny, R Brion, B Brulin, M Maillasson, C Charrier… - Cytokine, 2015 - Elsevier
Abstract Interleukin-34 (IL-34) is a newly-discovered homodimeric cytokine that regulates,
like Macrophage Colony-Stimulating Factor (M-CSF), the differentiation of the myeloid …
like Macrophage Colony-Stimulating Factor (M-CSF), the differentiation of the myeloid …
Colony-stimulating factor 1 receptor signaling in the central nervous system and the potential of its pharmacological inhibitors to halt the progression of neurological …
Abstract Colony Stimulating Factor-1 (CSF-1)/Colony Stimulating Factor-1 Receptor (CSF-
1R) signaling axis plays an essential role in the development, maintenance, and …
1R) signaling axis plays an essential role in the development, maintenance, and …
[HTML][HTML] Immunomodulation of interleukin-34 and its potential significance as a disease biomarker and therapeutic target
Y Ge, M Huang, Y Yao - International Journal of Biological …, 2019 - ncbi.nlm.nih.gov
Abstract Interleukin (IL)-34 is a cytokine discovered a few years ago and identified as the
second colony-stimulating factor (CSF)-1 receptor (CSF-1R) ligand. Although CSF-1 and IL …
second colony-stimulating factor (CSF)-1 receptor (CSF-1R) ligand. Although CSF-1 and IL …
IL-34 and CSF-1: similarities and differences
Y Nakamichi, N Udagawa, N Takahashi - Journal of bone and mineral …, 2013 - Springer
Abstract Colony-stimulating factor-1 (CSF-1) is widely expressed and considered to regulate
the development, maintenance, and function of mononuclear phagocyte lineage cells such …
the development, maintenance, and function of mononuclear phagocyte lineage cells such …
Down‐regulation of interleukin‐33 expression in oligodendrocyte precursor cells impairs oligodendrocyte lineage progression
HY Sung, WY Chen, HT Huang… - Journal of …, 2019 - Wiley Online Library
Abstract Interleukin‐33 (IL‐33), a member of the IL1 family, has been found to be expressed
in oligodendrocytes (OLGs) and released as an alarmin from injured OLGs to work on other …
in oligodendrocytes (OLGs) and released as an alarmin from injured OLGs to work on other …
CNS-specific synthesis of interleukin 23 induces a progressive cerebellar ataxia and the accumulation of both T and B cells in the brain: characterization of a novel …
L Nitsch, J Zimmermann, M Krauthausen… - Molecular …, 2019 - Springer
Abstract Interleukin 23 (IL-23) is a key mediator in neuroinflammation in numerous
autoimmune diseases including multiple sclerosis (MS). However, the pathophysiology of IL …
autoimmune diseases including multiple sclerosis (MS). However, the pathophysiology of IL …
Interleukin-36γ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis
L Bozoyan, A Dumas, A Patenaude… - Journal of …, 2015 - Springer
Background Experimental autoimmune encephalomyelitis (EAE) is a model of inflammatory
demyelinating diseases mediated by different types of leukocytes. How these cells …
demyelinating diseases mediated by different types of leukocytes. How these cells …
Induction of IL-33 expression and activity in central nervous system glia
IL-33 is a novel member of the IL-1 cytokine family and a potent inducer of type 2 immunity,
as mast cells and Th2 CD4+ T cells respond to IL-33 with the induction of type 2 cytokines …
as mast cells and Th2 CD4+ T cells respond to IL-33 with the induction of type 2 cytokines …