Immunomodulator CD200 promotes neurotrophic activity by interacting with and activating the fibroblast growth factor receptor
S Pankratova, H Bjornsdottir, C Christensen… - Molecular …, 2016 - Springer
The CD200 ligand is expressed by a variety of cell types, including vascular endothelia,
kidney glomeruli, some subsets of T and B cells, and neurons in the brain and periphery. In …
kidney glomeruli, some subsets of T and B cells, and neurons in the brain and periphery. In …
Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice
S Mathews, A Branch Woods, I Katano… - Molecular …, 2019 - Springer
Background Microglia are the principal innate immune defense cells of the centeral nervous
system (CNS) and the target of the human immunodeficiency virus type one (HIV-1). A …
system (CNS) and the target of the human immunodeficiency virus type one (HIV-1). A …
Regulation of an oligodendrocyte progenitor cell line by the interleukin‐6 family of cytokines
MA Kahn, J De Vellis - Glia, 1994 - Wiley Online Library
We report pleiotropic actions of the interleukin‐6 family of cytokines on a rat cerebral cortical
oligodendrocyte cell line, Central Glia‐4 (CG‐4). This is a bipotential oligodendrocyte type‐2 …
oligodendrocyte cell line, Central Glia‐4 (CG‐4). This is a bipotential oligodendrocyte type‐2 …
Production of IL‐27 in multiple sclerosis lesions by astrocytes and myeloid cells: modulation of local immune responses
V Sénécal, G Deblois, D Beauseigle, R Schneider… - Glia, 2016 - Wiley Online Library
The mechanisms whereby human glial cells modulate local immune responses are not fully
understood. Interleukin‐27 (IL‐27), a pleiotropic cytokine, has been shown to dampen the …
understood. Interleukin‐27 (IL‐27), a pleiotropic cytokine, has been shown to dampen the …
SIRP/CD47 signaling in neurological disorders
Microglia play important roles in the process of neuronal injury and recovery. Numeous
surface receptors have been described to regulate microglial activation. These receptors …
surface receptors have been described to regulate microglial activation. These receptors …
Increased expression of colony‐stimulating factor‐1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and …
S Gushchina, G Pryce, PK Yip, D Wu, P Pallier… - Glia, 2018 - Wiley Online Library
Microglia contribute to pathophysiology at all stages of multiple sclerosis. Colony‐
stimulating factor‐1 (CSF1) is crucial for microglial proliferation and activation. In this study …
stimulating factor‐1 (CSF1) is crucial for microglial proliferation and activation. In this study …
Analysis of IL‐6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin …
The interleukin (IL)‐6/gp130 family of cytokines (eg, IL‐6, IL‐11, leukemia inhibitory factor
(LIF) and oncostatin M (OSM)) play important roles in the central nervous system (CNS) …
(LIF) and oncostatin M (OSM)) play important roles in the central nervous system (CNS) …
Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system
D Allan, KJ Fairlie-Clarke, C Elliott, C Schuh… - Acta neuropathologica …, 2016 - Springer
Recent research findings have provided convincing evidence indicating a role for Interleukin-
33 (IL-33) signalling pathway in a number of central nervous system (CNS) diseases …
33 (IL-33) signalling pathway in a number of central nervous system (CNS) diseases …
Role of interleukin‐6 and soluble IL‐6 receptor in region‐specific induction of astrocytic differentiation and neurotrophin expression
P März, K Heese, B Dimitriades‐Schmutz… - Glia, 1999 - Wiley Online Library
Increasing evidence supports an essential role for interleukin‐6 (IL‐6) in the development,
differentiation, as well as de‐and re‐generation of neurons in the central nervous system …
differentiation, as well as de‐and re‐generation of neurons in the central nervous system …
Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development
Neuronal synapse formation and remodeling are essential to central nervous system (CNS)
development and are dysfunctional in neurodevelopmental diseases. Innate immune …
development and are dysfunctional in neurodevelopmental diseases. Innate immune …