Introduction: Rho GTPases are master regulators of actomyosin structure and dynamics and
play pivotal roles in a variety of cellular processes including cell morphology, gene …

Accumulating evidence from basic and clinical studies supports the concept that signaling
pathways downstream of Rho GTPases play important roles in tumor development and …

Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular
functions associated with malignant transformation and metastasis. Rho GTPases are …

Rho GTPases regulate cellular morphology and dynamics, and some are key drivers of
cancer progression. This superfamily offers attractive potential targets for therapeutic …

RHO GTPases, members of the RAS superfamily of small GTPases, are adhesion and
growth factor–activated molecular switches that play important roles in tumor development …

RHO GTPases have been traditionally associated with protumorigenic functions. While this
paradigm is still valid in many cases, recent data have unexpectedly revealed that RHO …

As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of
cellular processes, including cell polarity, cell migration, and cell cycle progression. The …

In vitro and in vivo studies and evidence from human tumors have long implicated Rho
GTPase signaling in the formation and dissemination of a range of cancers. Recently next …

Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …

Abstract The Rho GTPases RhoA, Rac1, and Cdc42 are important regulators of cytoskeletal
dynamics. Although many in vitro and in vivo data indicate tumor-promoting effects of …