Adult mesenchymal stem cells and their exosomes: Sources, characteristics, and application in regenerative medicine

M Maqsood, M Kang, X Wu, J Chen, L Teng, L Qiu - Life sciences, 2020 - Elsevier
Human mesenchymal stem cells (MSCs) have become a hot topic in the development of cell
therapies and bioengineering. All kinds of MSCs are genomic stable and have the self …

[HTML][HTML] Mesenchymal stromal/stem cells spheroid culture effect on the therapeutic efficacy of these cells and their exosomes: A new strategy to overcome cell therapy …

A Hazrati, K Malekpour, S Soudi… - Biomedicine & …, 2022 - Elsevier
Cell therapy is one of the new treatment methods in which mesenchymal stem/stromal cell
(MSCs) transplantation is one of the cells widely used in this field. The results of MSCs …

Mesenchymal stem cell exosomes

RC Lai, RWY Yeo, SK Lim - Seminars in cell & developmental biology, 2015 - Elsevier
MSCs are an extensively used cell type in clinical trials today. The initial rationale for their
clinical testing was based on their differentiation potential. However, the lack of correlation …

Current knowledge and future perspectives on mesenchymal stem cell-derived exosomes as a new therapeutic agent

HS Joo, JH Suh, HJ Lee, ES Bang, JM Lee - International journal of …, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) are on the cusp of regenerative medicine due to their
differentiation capacity, favorable culture conditions, ability to be manipulated in vitro, and …

Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities

A Hassanzadeh, HS Rahman, A Markov… - Stem cell research & …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) and their widespread biomedical
applications have attracted great consideration from the scientific community around the …

Free and hydrogel encapsulated exosome-based therapies in regenerative medicine

A Akbari, N Jabbari, R Sharifi, M Ahmadi, A Vahhabi… - Life sciences, 2020 - Elsevier
Over the last few decades, mesenchymal stem cells-derived exosomes (MSCs-Ex) have
attracted a lot of attention as a therapeutic tool in regenerative medicine. Exosomes are …

[HTML][HTML] Mesenchymal stem cell-derived exosomes: new opportunity in cell-free therapy

DP Sarvar, K Shamsasenjan… - Advanced …, 2016 - ncbi.nlm.nih.gov
Mesenchymal stromal/stem cells (MSCs) are involved in tissue homeostasis through direct
cell-to-cell interaction, as well as secretion of soluble factors. Exosomes are the sort of …

Focus on mesenchymal stem cell‐derived exosomes: opportunities and challenges in cell‐free therapy

L Cheng, K Zhang, S Wu, M Cui, T Xu - Stem cells international, 2017 - Wiley Online Library
Mesenchymal stem cells have been at the forefront of regenerative medicine for many years.
Exosomes, which are nanovesicles involved in intercellular communication and the …

Boosting the biogenesis and secretion of mesenchymal stem cell-derived exosomes

J Wang, EE Bonacquisti, AD Brown, J Nguyen - Cells, 2020 - mdpi.com
A limitation of using exosomes to their fullest potential is their limited secretion from cells, a
major bottleneck to efficient exosome production and application. This is especially true for …

[HTML][HTML] Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation

MR Showalter, B Wancewicz, O Fiehn… - Biochemical and …, 2019 - Elsevier
Mesenchymal stem cell (MSC) based therapies are currently being evaluated as a putative
therapeutic in numerous human clinical trials. Recent reports have established that …