Strategies for blocking the systemic effects of cytokines in... : Critical Care Medicine Strategies
for blocking the systemic effects of cytokines in the sepsis syndrome : Critical Care Medicine …

A prevailing hypothesis is that at low levels cytokines perform important homeostatic actions
that regulate immunologic and physiologic events. At higher concentrations, cytokines can …

Several clinical trials have attempted to treat sepsis by blocking certain aspects of the
inflammatory response. Tumor necrosis factor and interleukin 1 have been specific targets …

Current prospects for the treatment of clinical sepsis. - Abstract - Europe PMC Sign in |
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Although data with regard to cytokine action are rapidly emerging at the molecular and cell
level, animal and human data are lagging. Deciphering the mechanisms of action and …

Sepsis syndrome and septic shock remain significant causes of morbidity and mortality. To
date, clinical trials of novel agents to treat sepsis have failed to demonstrate clinical efficacy …

Sepsis is a clinical syndrome that results from a systemic response of the host to an
infection. Activation of inflammatory pathways, including the cytokine network, is considered …

Sepsis is currently listed as the 13th leading cause of death in the United States, and it is on
the rise. Factors thought to account for this recent increase include an aging population …

Despite often knowing the aetiology of sepsis and its clinical course there has not been the
anticipated advances in treatment strategies. Cytokines are influential mediators of …

Human sepsis is characterized by a profound stimulation of the immune system. This results
in the activation of multiple biological cascades, including inflammation (cytokines …