CRISPR-mediated genome editing has undoubtedly revolutionized genetic engineering of
animals. With the ability for virtually unlimited modification of almost any genome it is easy to …

The first genetically modified large animals were developed in 1985 by microinjection to
increase the growth of agricultural livestock such as pigs. Since then, it has been a difficult …

Background The simplicity of the CRISPR/Cas9 system has enabled its widespread
applications in generating animal models, functional genomic screening and in treating …

The use of animal models, particularly rodents, has been immensely important to nearly all
aspects of biomedical research, from basic science exploration to translational discoveries …

Accelerated development of novel CRISPR/Cas9-based genome editing techniques
provides a feasible approach to introduce a variety of precise modifications in the …

The CRISPR–Cas system is the newest targeted nuclease for genome engineering. In less
than 1 year, the ease, robustness and efficiency of this method have facilitated an immense …

Contents In the last decade, the research community has witnessed a blooming of targeted
genome editing tools and applications. Novel programmable DNA nucleases such as zinc …

Genome editing by programmable RNA-dependent Cas endonucleases has revolutionised
the field of genome engineering, achieving targeted genomic change at unprecedented …

The rabbit has been recognized as a valuable model in various biomedical and biological
research fields because of its intermediate size and phylogenetic proximity to primates …

Genetic modification of almost any species is now possible using approaches based on
targeted nucleases. These novel tools now bypass previous limited species windows …