Ten years of remarkable progress in understanding the fundamental biochemistry of
Alzheimer's disease have been followed by ten years of remarkable and increasing clinical …

Degenerative diseases of the brain were long considered among the most obscure and
intractable of human maladies. However, recent advances in understanding their …

The bulk of AD research during the last 25 years has been Aβ-centric based on a strong faith
in the Amyloid Cascade Hypothesis which is not supported by the data on humans. To date …

Amyloidopathies cause neurodegeneration in a substantial portion of the elderly population.
Improvements in long term health care have made elderly individuals a large and growing …

It is now 100 years since the nosological definition of Alzheimer's disease emerged. In the
first 80 years, very little progress was made in understanding the mechanisms that caused …

Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …

Alzheimer's disease (AD) is characterized clinically by dementia and pathologically by two
hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago …

Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Genetic studies of autosomal dominant Alzheimer's disease (AD) revealed that β-amyloid is
central to disease pathogenesis. However, amyloid-targeted therapies have generally failed …

There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …