Background Protein neddylation plays a tumor-promoting role in esophageal cancer. Our
previous study demonstrated that neddylation inhibition induced the accumulation of ATF4 …

Purpose: Targeting the protein neddylation pathway has become an attractive anticancer
strategy; however, the role of death receptor–mediated extrinsic apoptosis during treatment …

The neddylation pathway is overactivated in esophageal cancer. Our previous studies
indicated that inactivation of neddylation by the NAE inhibitor induced apoptosis and …

Neddylation is a post-translational protein modification process. MLN4924 is a newly
discovered pharmaceutical neddylation inhibitor that suppresses cancer growth with several …

Abstract Background PI3K-Akt pathway activation and the expression of histone
deacetylases (HDACs) are highly increased in esophageal cancer, suggesting that …

MLN4924, a newly discovered small molecule inhibitor of NEDD8-activating enzyme (NAE),
inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin neddylation. As a …

Liver cancer is the second-most frequent cause of cancer death in the world and is highly
treatment resistant. We reported previously that inhibition of neddylation pathway with …

Posttranslational neddylation of cullins in the Cullin-Ring E3 ligase (CRL) complexes is
needed for proteolytic degradation of CRL substrates, whose accumulation induces cell …

Therapeutic intervention in neddylation pathway is an emerging area for cancer treatment.
Herein, we evaluated the clinical relevance and therapeutic potential of targeting this …

Tight junction is a structural constitution in cell–cell adhesion and play an important role in
the maintenance of permeability and integrity of normal epithelial cell barrier. The protein …