Hypoxia-inducible factor 1α (HIF-1α) is rapidly degraded by the ubiquitin-proteasome
pathway under normoxic conditions. Ubiquitination of HIF-1α is mediated by interaction with …

Abstract Hypoxia-inducible factor-1α (HIF-1α) is a master transcription factor that is critical for
the regulation of a variety of cellular functions. HIF-1α is rapidly degraded under normoxic …

Abstract Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator,
which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 …

The hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that mediates adaptive
cellular responses to decreased oxygen availability (hypoxia). At normoxia, HIF-1α is …

Under normoxic conditions the alpha-subunit of hypoxia-inducible factor (HIF-1α) protein is
targeted for degradation by the von Hippel-Lindau (VHL) tumor suppressor protein acting as …

Hypoxia plays a major role in the induction of angiogenesis during tumor development. One
mechanism by which tumor cells respond to a reduced oxygen level is via the activation of …

Many human diseases are characterized by the development of tissue hypoxia. Hypoxia-
inducible factor (HIF) is a transcription factor that regulates fundamental cellular processes …

In normoxic cells the hypoxia‐inducible factor‐1α (HIF‐1α) is rapidly degraded by the
ubiquitin‐proteasome pathway, and activation of HIF‐1α to a functional form requires protein …

Abstract Hypoxia-inducible factor-1α (HIF-1α) is destabilized via the ubiquitin–proteasome
system. Thus HIF-1α expression is robustly upregulated by proteasome inhibition, but …

The hypoxia-inducible factor 1α (HIF-1α) is the master regulator of the cellular response to
hypoxia. A key regulator of HIF-1α is von Hippel-Lindau protein (pVHL), which mediates the …