Most solid tumors and their metastases experience periods of low oxygen or hypoxia, which
is of major clinical significance as it promotes both tumor progression and resistance to …

Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

Complex circulatory and respiratory systems are established during embryonic development
and used in fetal and postnatal life to ensure oxygen delivery to every cell in the human …

HIF-1 (hypoxia-inducible factor-1), a heterodimeric transcription factor comprising HIF-1α
and HIF-1β subunits, serves as a key regulator of metabolic adaptation to hypoxia. HIF-1 …

In the presence of oxygen and iron, hypoxia-inducible factor (HIF-1α) is rapidly degraded via
the prolyl hydroxylases (PHD)/VHL pathways. Given striking similarities between p53 and …

Hypoxia-inducible factor-1α (HIF-1α) plays a central role in oxygen homeostasis. In
normoxia, HIF-1α is a short lived protein, whereas hypoxia rapidly increases HIF-1α protein …

The hypoxia-inducible transcription factors (HIF) 1α and HIF-2α play a critical role in cellular
response to hypoxia. Elevated HIF-α expression correlates with poor patient survival in a …

Hypoxia-inducible factor-1α (HIF-1α) 1 is a global transcriptional regulator of the hypoxic
response. Under normoxic conditions, HIF-1α is recognized by the von Hippel-Lindau tumor …

Adaptation to hypoxic microenvironment is critical for tumor survival and metastatic spread.
Hypoxia-inducible factor 1α (HIF-1α) plays a key role in this adaptation by stimulating the …

Hypoxia and induction of hypoxia-inducible factors (HIF-1α and HIF-2α) is a hallmark of
many tumors. Under normal oxygen tension HIF-alpha subunits are rapidly degraded …