Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls
angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes …

Under hypoxia, HIF-1α binds to aryl hydrocarbon receptor nuclear translocator (ARNT, also
called HIF-1β) to activate expression of genes important for cell survival. Alternatively, HIF …

Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …

The transcriptional activator complex HIF-1 plays a key role in the long term adaptation of
cells and tissues to their hypoxic microenvironment by stimulating the expression of genes …

Background Homeodomain-interacting protein kinase-2 (HIPK2), a transcriptional co-
repressor with apoptotic function, can affect hypoxia-inducible factor 1 (HIF-1) transcriptional …

Stabilization of the hypoxia-inducible factor-1 (HIF-1) protein is essential for its role as a
regulator of gene expression under low oxygen conditions. Here, employing a novel …

Hypoxia inducible factor 1 (HIF-1), a heterodimeric transcription factor composed of HIF-1α
and HIF-1β subunits, serves as a key regulator of metabolic adaptation to hypoxia. The …

Hypoxia inducible factor (HIF) is important in cancer, as it regulates various oncogenic
genes as well as genes involved in cell survival, proliferation, and migration. Elevated HIF-1 …

Hypoxia-inducible factors (HIFs) are master regulators of adaptive responses to low oxygen,
and their α-subunits are rapidly degraded through the ubiquitination-dependent …

Hypoxia inducible factor (HIF) is the major transcription factor involved in the regulation of
the cellular response to hypoxia, or low oxygen tensions. Even though HIF-1 function is …