Hypoxia inducible factors (HIFs) are activated in many tumors and show either promoter or
suppressor activity, depending on tumor cell biology and background. However, the role of …

Hypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly
multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic …

The hypoxia-inducible factor (HIF) 1α is a key regulator of the cellular response to oxygen
deprivation. Specific disruption of the HIF-1 pathway is important for exploring its role in …

Hypoxia-inducible factor 1 (HIF-1) plays a critical role in controlling oxygen delivery and
metabolic adaptation to hypoxic conditions in hypoxic tumor cells. HIF-1 activation is initiated …

Abstract Background/Aims: Hypoxia Inducible Factor-1α (HIF-1α) is involved in cancer
progression and is stabilized by the chaperone HSP90 (Heat Shock Protein 90), preventing …

Hypoxia induces a group of physiologically important genes such as erythropoietin and
vascular endothelial growth factor. These genes are transcriptionally up-regulated by …

Hypoxia-inducible factors (HIFs) are heterodimeric oxygen-sensitive basic helix-loop-helix
transcription factors that play central roles in cellular adaptation to low oxygen environments …

Recently, work on the mechanism of action of the von Hippel–Lindau tumour suppressor
protein (pVHL) and studies on hypoxic gene regulation have converged, providing insights …

The hypoxia-inducible factors HIF-1α and HIF-2α are structurally similar as regards their
DNA-binding and dimerization domains, but differ in their transactivation domains and, as is …

The hypoxia-inducible transcription factor-1 (HIF-1) is central to a number of pathological
processes through the induction of specific genes such as vascular endothelial growth factor …