During embryogenesis, the endothelial and the hematopoietic lineages first appear during
gastrulation in the blood island of the yolk sac. We have previously reported that an Ets …

Transcription factors of the ETS family are important regulators of endothelial and
hematopoietic development. We have characterized the Xenopus orthologue of the ETS …

Etv2 is a master gene for the commitment of hematopoietic/endothelial cells and is a potent
inducer of endothelial/hematopoietic cells from embryonic stem cells. Etv2 is highly …

During mouse embryogenesis the first hematopoietic and endothelial cells form in blood
islands located between layers of visceral endoderm and mesoderm in the yolk sac. The …

Etv2 is an essential transcriptional regulator of hematoendothelial lineages during
embryogenesis. Although Etv2 downstream targets have been identified, little is known …

Abstract Extra-embryonic mesoderm (ExM)—composed of the earliest cells that traverse the
primitive streak—gives rise to the endothelium as well as haematopoietic progenitors in the …

Background: ETV2 has been identified as an important player in embryonic hematopoiesis.
However, the cell populations in which this transcription factor is expressed and operates …

Etv2, an Ets-transcription factor, governs the specification of the earliest hemato-endothelial
progenitors during embryogenesis. While the transcriptional networks during hemato …

The contribution of the different waves and sites of developmental hematopoiesis to fetal
and adult blood production remains unclear. Here, we identify lymphatic vessel endothelial …

Yolk sac (YS) hematopoiesis is critical for the survival of the embryo and a major source of
tissue-resident macrophages that persist into adulthood. Yet, the transcriptional and …