Assessing the usefulness of anticardiolipin antibody assays: a cautious approach is suggested by high variation and limited consensus in multilaboratory testing

EJ Favaloro, R Silvestrini - American journal of clinical pathology, 2002 - academic.oup.com
An anticardiolipin antibody (ACA) assay has become a laboratory standard for the detection
of antiphospholipid antibodies. We evaluated data from a quality assurance program to …

Clinical utility of anticardiolipin antibody assays: high inter-laboratory variation and limited consensus by participants of external quality assurance programs signals a …

EJ Favaloro, R Silvestrini, A Mohammed - Pathology, 1999 - Elsevier
Antibodies that bind phospholipid (anti-phospholipid antibodies [APA]) are a focus of major
interest to both clinical and laboratory personnel across a variety of disciplines because of …

Special report. The Second International Anti-cardiolipin Standardization Workshop/the Kingston Anti-Phospholipid Antibody Study (KAPS) group.

EN Harris - American Journal of Clinical Pathology, 1990 - europepmc.org
Forty-three laboratories in 13 countries participated in a workshop to determine the degree
of agreement between laboratories performing anticardiolipin tests. Each laboratory …

The second international anti-cardiolipin standardization workshop/the Kingston anti-phospholipid antibody study (KAPS) group

EN Harris - American Journal of Clinical Pathology, 1990 - academic.oup.com
Forty-three laboratories in 13 countries participated in a workshop to determine the degree
of agreement between laboratories performing anticardiolipin tests. Each laboratory …

[HTML][HTML] Influence of different IgG anticardiolipin antibody cut‐off values on antiphospholipid syndrome classification

A Ruffatti, S Olivieri, M Tonello, M Bortolati… - Journal of Thrombosis …, 2008 - Elsevier
Background: While medium to high titers of anticardiolipin (aCL) antibodies, defined as> 40
GPL units or> 99th percentile, is a laboratory criteria for the 'definite'diagnosis of …

[HTML][HTML] A re‐appraisal of the normal cut‐off assignment for anticardiolipin IgM tests

R Budd, E Harley, A Quarshie, V Henderson… - Journal of Thrombosis …, 2006 - Elsevier
Background: Recent reports show an apparent large number of individuals with low to
moderate titers of anticardiolipin antibodies (ACA), particularly of the IgM isotype with no …

Accuracy of the First Fully Automated Method for Anti‐cardiolipin and Anti‐β2 Glycoprotein I Antibody Detection for the Diagnosis of Antiphospholipid Syndrome

D Villalta, MG Alessio, M Tampoia… - Annals of the New …, 2009 - Wiley Online Library
In this study we evaluated the diagnostic accuracy for antiphospholipid syndrome (APS) of
new fully automated immunoassays for anticardiolipin (aCL) and anti‐β2 glycoprotein I (anti …

Optimising testing for phospholipid antibodies

M Helbert, S Bodger, J Cavenagh, D D'Cruz… - Journal of clinical …, 2001 - jcp.bmj.com
Aim—To compare anticardiolipin (ACL) and anti-β2 glycoprotein 1 (β2gp1) enzyme linked
immunosorbent assays (ELISAs) in the diagnosis of antiphospholipid syndrome (APS) and …

Antiphospholipid antibody testing for the antiphospholipid syndrome: a comprehensive practical review including a synopsis of challenges and recent guidelines

EJ Favaloro, RCW Wong - Pathology, 2014 - Elsevier
The antiphospholipid (antibody) syndrome (APS) is an autoimmune condition characterised
by a wide range of clinical features, but primarily identified as thrombotic and/or obstetric …

Antiphospholipid antibody ELISAs: Survey on the performance of clinical laboratories assessed by using lyophilized affinity-purified IgG with anticardiolipin and anti …

V Pengo, A Biasiolo, E Bison, V Chantarangkul… - Thrombosis research, 2007 - Elsevier
Lupus anticoagulant (LA) and anticardiolipin (aCL) antibodies are the classical tests used to
diagnose the antiphospholipid syndrome (APS). Unfortunately, since these are nonspecific …