Converting short-acting insulin into thermo-stable longer-acting insulin using multi-layer detachable microneedles
T Phoka, N Wanichwecharungruang… - Journal of …, 2024 - Elsevier
The detachable dissolving microneedles (DDMNs) feature an array of needles capable of
being separated from the base sheet during administration. Here they were fabricated to …
being separated from the base sheet during administration. Here they were fabricated to …
Dissolving polymer microneedles for transdermal delivery of insulin
N Zhang, X Zhou, L Liu, L Zhao, H Xie… - Frontiers in …, 2021 - frontiersin.org
It's of great significance to develop insulin-loaded dissolving microneedles (MNs) which are
fabricated with various methods and materials for transdermal delivery of insulin to …
fabricated with various methods and materials for transdermal delivery of insulin to …
Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity
Recently, numerous transdermal drug delivery systems have been developed for safe and
efficient delivery of biopharmaceuticals. Dissolving microneedles (DMNs) are one such drug …
efficient delivery of biopharmaceuticals. Dissolving microneedles (DMNs) are one such drug …
Two-layered dissolving microneedles formulated with intermediate-acting insulin
Y Ito, M Hirono, K Fukushima, N Sugioka… - International journal of …, 2012 - Elsevier
Two-layered dissolving microneedles (DMs) containing intermediate-acting insulin,
protamine sulfate insulin (PSI), were prepared. Then a pharmacodynamic study was …
protamine sulfate insulin (PSI), were prepared. Then a pharmacodynamic study was …
Innovative freeze-drying technique in the fabrication of dissolving microneedle patch: Enhancing transdermal drug delivery efficiency
T Su, Z Tang, J Hu, Y Zhu, T Shen - Drug Delivery and Translational …, 2024 - Springer
Microneedle patch (MNP) has become a hot research topic in the field of transdermal drug
delivery due to its ability to overcome the stratum corneum barrier. Among the various types …
delivery due to its ability to overcome the stratum corneum barrier. Among the various types …
Formulation of two‐layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice
Dissolving microneedles (MNs) display high efficiency in delivering poorly permeable drugs
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …
and vaccines. Here, two‐layer dissolving polymeric MN patches composed of gelatin and …
Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats
MH Ling, MC Chen - Acta biomaterialia, 2013 - Elsevier
This study presents a dissolving microneedle patch, composed of starch and gelatin, for the
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …
rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve …
Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery
S Lau, J Fei, H Liu, W Chen, R Liu - Journal of Controlled Release, 2017 - Elsevier
Dissolving microneedles have been employed as a safe and convenient transdermal
delivery system for drugs and vaccines. To improve effective drug delivery, a multilayered …
delivery system for drugs and vaccines. To improve effective drug delivery, a multilayered …
Microneedles with two-stage glucose-sensitive controlled release for long-term insulin delivery
Y Wang, H Yu, L Wang, J Hu, J Feng… - ACS Biomaterials …, 2023 - ACS Publications
Diabetes patients cannot complete effective blood glucose regulation due to their impaired
pancreatic function. At present, subcutaneous insulin injection is the only treatment for …
pancreatic function. At present, subcutaneous insulin injection is the only treatment for …
Glucose-responsive insulin microneedle patches for long-acting delivery and release visualization
Y He, N Chen, M Zang, J Zhang, Y Zhang, H Lu… - Journal of Controlled …, 2024 - Elsevier
Limited drug loading and incomplete drug release are two major obstacles that traditional
polymeric microneedles (MNs) have to overcome. For smart controlled-release MNs, since …
polymeric microneedles (MNs) have to overcome. For smart controlled-release MNs, since …