Applications and approaches for three-dimensional precision-cut lung slices. Disease modeling and drug discovery

HN Alsafadi, FE Uhl, RH Pineda, KE Bailey… - American journal of …, 2020 - atsjournals.org
Chronic lung diseases (CLDs), such as chronic obstructive pulmonary disease, interstitial
lung disease, and lung cancer, are among the leading causes of morbidity globally and …

Intravital fluorescence microscopy in pulmonary research

CMS Croix, K Leelavanichkul, SC Watkins - Advanced drug delivery …, 2006 - Elsevier
Over the last several years, microscopy as a scientific tool has reinvented itself evolving from
a group of principally descriptive methodologies to encompass a wide range of primary tools …

Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

J Petersson, A Sánchez-Crespo… - Journal of applied …, 2007 - journals.physiology.org
Emission tomography provides three-dimensional, quantitative images of the distribution of
radiotracers used to mark physiological, metabolic, or pathological processes. Quantitative …

Detection of lung dysfunction using ventilation and perfusion SPECT in a mouse model of chronic cigarette smoke exposure

BN Jobse, RG Rhem, IQ Wang… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality
worldwide. Exposure to cigarette smoke (CS) is a major risk factor for developing this …

Recent advances in fluorescence imaging of pulmonary fibrosis in animal models

Z Liu, X Tang, Z Zhu, X Ma, W Zhou… - Frontiers in Molecular …, 2021 - frontiersin.org
Pulmonary fibrosis (PF) is a lung disease that may cause impaired gas exchange and
respiratory failure while being difficult to treat. Rapid, sensitive, and accurate detection of …

Crystal ribcage: a platform for probing real-time lung function at cellular resolution

R Banerji, GN Grifno, L Shi, D Smolen, R LeBourdais… - Nature …, 2023 - nature.com
Understanding the dynamic pathogenesis and treatment response in pulmonary diseases
requires probing the lung at cellular resolution in real time. Despite advances in intravital …

[图书][B] Models of lung disease: microscopy and structural methods

J Gil - 2020 - books.google.com
This research-level reference provides a review of the morphological techniques that have
become a primary method of anatomical study correlating structure and function in lung …

Optical imaging of molecular signatures in pulmonary inflammation

V Ntziachristos - Proceedings of the American Thoracic Society, 2009 - atsjournals.org
Biomedical imaging has become an important tool in the study of “-omics” fields by allowing
the noninvasive visualization of functional and molecular events using in vivo staining and …

Live imaging of the lung

T Brzoska, TW Kaminski… - Current protocols in …, 2020 - Wiley Online Library
Live imaging is critical to determining the dynamics and spatial interactions of cells within
the tissue environment. In the lung, this has proven to be difficult due to the motion brought …

Models and approaches to understand the role of airway remodelling in disease

RJ McAnulty - Pulmonary pharmacology & therapeutics, 2011 - Elsevier
Airway remodelling is a collective term for changes in the amount or organisation of the
cellular and molecular constituents of the airway wall. Remodelling occurs in and is …