The Discovering New Therapeutic Uses for Existing Molecules pilot program, led by the
National Center for Advancing Translational Sciences (NCATS), uses innovative strategies …

The field of diagnostics has unprecedented opportunities to contribute to the practice of
medicine in the era of targeted therapy and personalized healthcare. Rather than simply …

Translational research is the collaboration between scientists and clinicians to identify novel
targets and develop biomarkers that increase confidence in rationale and therefore help …

Importance of the field: The number of disease-associated protein targets has significantly
increased over the past decade due to advances in molecular and cellular biology …

The complexity of human disease results in numerous opportunities for disease pathology to
circumvent the effectiveness of a drug against a single molecular target. Clinicians in …

In this paper, we examine the clinical and economic challenges that face developers of and
payers for personalized drugs and companion diagnostics. We review and summarize …

Low productivity in the pharmaceutical industry positions personalized medicine and
companion diagnostics as an attractive approach. The oncology community is enthusiastic …

The strategic, fit-for-purpose use of the combination of robust target engagement and well-
qualified disease-related biomarkers enhances understanding of the mechanism of action …

This perspective emphasizes the role of quantitative translational pharmacology to bridge
science and practice to make better, faster, and efficient decisions in drug discovery and …

On 1–2 December 2010 worldwide leaders in the field of co-diagnostics gathered in Boston,
MA, USA, to discuss the state of predictive medicine and the complexities of biomarker …