Despite successes with new drug approvals over the past two decades through
conventional drug development approaches, many human diseases remain intractable to …

With the rapid advancement of scientific understanding in the medical field, everyday use of
personalized medicine appears within our grasp. Unfortunately, there are still challenges to …

Pharmacogenomics (PGx) provides information on inter-individual genetic variability that
can be used to “personalize” therapeutic regimes by predicting drug efficacy, patient clinical …

Policy makers, health professionals, research leaders, and funders in academia and
industry interested in healthcare have a major current challenge. What to do about …

Low target discovery rate has been linked to inadequate consideration of multiple factors
that collectively contribute to druggability. These factors include sequence, structural …

Abstract Information from genomic, proteomic and metabolomic measurements has already
benefited target discovery and validation, assessment of efficacy and toxicity of compounds …

In this article, we discuss the merits of both target-based and phenotypic screening
strategies to find starting points for drug discovery projects in neglected tropical disease …

This perspective emphasizes the role of quantitative translational pharmacology to bridge
science and practice to make better, faster, and efficient decisions in drug discovery and …

Maximizing the commercial value of personalized therapeutics and companion diagnostics |
Nature Biotechnology Skip to main content Thank you for visiting nature.com. You are using a …

In any therapeutics discovery and development effort, multiple critical steps must be
accomplished to arrive at a compound that is safe and efficacious, while also exhibiting the …