The endocannabinoid system (ECS) employs a huge network of molecules (receptors,
ligands, and enzymatic machinery molecules) whose interactions with other cellular …

Rapidly increasing worldwide prevalence of obesity and related pathologies encompassing
coronary heart disease, hypertension, metabolic syndrome, or type 2 diabetes constitute …

Endocannabinoid signalling is considered one of the most important modulatory systems in
a whole organism. Research has yielded great insight on the mechanisms that link …

The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Metabolic syndrome is a complex disease state, which appears mostly as a consequence of
an unhealthy, sedentary lifestyle. Metabolic complications include insulin resistance (IR) …

Highlights•Increased emphasis in recent years on drugs targeting the endocannabinoid
system.•Recent discoveries about the role of the endocannabinoid system are …

The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …

The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …