We have previously reported that colorectal cancer (CRC) liver metastases from patients,
who had received the selective cyclooxygenase 2 (COX-2) inhibitor rofecoxib (Vioxx) 25 mg …

Background & Aims: Cyclooxygenase-2 (COX-2) is a potential target for chemotherapy of
colorectal cancer (CRC). We tested the antineoplastic activity of the selective COX-2 …

TO THE EDITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most
commonly used medications in the world. Gastrointestinal toxicity is the main limiting factor …

TO THE EDITOR: Administration of nonselective, nonsteroidal anti-inflammatory drugs that
inhibit both cyclo-oxygenase-1 (COX-1) and COX-2 to patients with cirrhosis may cause …

Asculum. However, the cost was great, as he had lost irreplaceable troops and comrades;
the Romans would eventually be able to regroup in greater numbers than ever. A quote …

Herein we describe a patient who developed symptomatic cholestatic liver disease as a
result of long-term use of rofecoxib (Vioxx). Rofecoxib is a novel selective COX-2 inhibitor …

Most epithelial cancers, including those of the digestive tract, show overexpression of COX-
2, an inducible enzyme controlling prostaglandin synthesis. The upregulation of COX-2 in …

Background Angiogenesis is required for growth and metastasis of colorectal cancer (CRC),
and several positive regulators of tumor angiogenesis have been identified …

Sir, Nonsteroidal anti-inflammatory drugs are among the most widely used of all drugs and
are the most common medications used in persons aged 65 years or more. In recent years …

Materials and methods COX-2 expression of 6 kinds of human colon cancer cell lines, with
various potentials for liver metastasis, were assessed by Western blot and reverse …