Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury

BJ Kerr, WBJ Cafferty, YIK Gupta… - European Journal of …, 2000 - Wiley Online Library
The neuropeptide galanin has been identified as a potential neurotransmitter/
neuromodulator within the central nervous system. In the present study, the role of …

Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury

K Hygge-Blakeman, P Brumovsky, JX Hao, XJ Xu… - Brain research, 2004 - Elsevier
The neuropeptide galanin may have a role in modulation of nociception, particularly after
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …

Use of genetically engineered transgenic mice to investigate the role of galanin in the peripheral nervous system after injury

FE Holmes, SA Mahoney, D Wynick - Neuropeptides, 2005 - Elsevier
The neuropeptide galanin is present at high levels within the dorsal root ganglia (DRG) and
spinal cord during development and after peripheral nerve damage in the adult. This pattern …

Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse—possible implications for pain processing

P Brumovsky, K Hygge-Blakeman, MJ Villar… - Journal of Chemical …, 2006 - Elsevier
The distribution of galanin was studied in the lumbar 5 dorsal root ganglia (DRGs) and
spinal cord, superior cervical ganglia (SCGs), and skin of transgenic mice overexpressing …

Endogenous galanin potentiates spinal nociceptive processing following inflammation

BJ Kerr, Y Gupta, R Pope, SWN Thompson, D Wynick… - Pain, 2001 - journals.lww.com
We have undertaken a series of experiments using galanin null mutant mice to better define
the role of endogenous galanin in spinal excitability following inflammation and in response …

Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia

RP Hulse, D Wynick, LF Donaldson - Molecular pain, 2011 - journals.sagepub.com
Background: Galanin is expressed at low levels in the intact sensory neurons of the dorsal
root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also …

Galanin and spinal nociceptive mechanisms: recent results from transgenic and knock-out models

Z Wiesenfeld-Hallin, XJ Xu, JN Crawley, T Hökfelt - Neuropeptides, 2005 - Elsevier
Genetically modified mice with transgenic overexpression of galanin or depletion of genes
for galanin or galanin receptors have become available, providing a new approach for …

Peripheral galanin receptor 2 as a target for the modulation of pain

RP Hulse, LF Donaldson… - Pain research and …, 2012 - Wiley Online Library
The neuropeptide galanin is widely expressed in the nervous system and has an important
role in nociception. It has been shown that galanin can facilitate and inhibit nociception in a …

Intrathecal galanin alleviates allodynia‐like behaviour in rats after partial peripheral nerve injury

JX Hao, TJ Shi, IS Xu, T Kaupilla, XJ Xu… - European Journal Of …, 1999 - Wiley Online Library
We have previously suggested that the neuropeptides galanin and galanin message‐
associated peptide (GMAP) may have an inhibitory role in spinal nociception. The present …

Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior

FE Holmes, A Bacon, RJP Pope… - Proceedings of the …, 2003 - National Acad Sciences
The neuropeptide galanin is expressed in the dorsal root ganglia (DRG) and spinal cord and
is thought to be involved in the modulation of pain processing. However, its mechanisms of …