Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes
(T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA …

Pancreatic islets consist of multiple cell types that produce hormones required for glucose
homeostasis, and islet dysfunction is a major factor in type 1 and type 2 diabetes. Numerous …

Identifying cis-regulatory elements is important to understanding how human pancreatic
islets modulate gene expression in physiologic or pathophysiologic (eg, diabetic) conditions …

The pancreatic islet is a highly specialized tissue embedded in the exocrine pancreas
whose primary function is that of controlling glucose homeostasis. Thus, understanding the …

Blood glucose levels are tightly controlled by the coordinated action of at least four cell types
constituting pancreatic islets. Changes in the proportion and/or function of these cells are …

Genome-wide association studies (GWASs) identified hundreds of signals associated with
type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have …

The majority of gene loci that have been associated with type 2 diabetes play a role in
pancreatic islet function. To evaluate the role of islet gene expression in the etiology of …

Genome-wide association studies (GWAS) have identified> 100 independent SNPs that
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …

Efforts to phenotype pancreatic islets have contributed tremendously to our present
understanding of endocrine function and diabetes. A continued evolution in approaches to …

In type 1 diabetes (T1D), the insulin-producing β cells are destroyed by an immune-
mediated process leading to complete insulin deficiency. There is a strong genetic …