Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats

L Vyklický, H Knotková-Urbancová… - Journal of …, 1998 - journals.physiology.org
Vyklický, Ladislav, Helena Knotková-Urbancová, Zdeňka Vitásková, Viktorie Vlachová,
Michaela Kress, and Peter W. Reeh. Inflammatory mediators at acidic pH activate capsaicin …

Low pH facilitates capsaicin responses in isolated sensory neurons of the rat

M Kress, S Fetzer, PW Reeh, L Vyklicky - Neuroscience letters, 1996 - Elsevier
The effects of capsaicin (CAPS; 30 nM, 300 nM, 3 μM) and acidic solutions (pH 6.6, 6.1, 5.6,
5.1) were studied in dorsal root ganglion (DRG) neurons from adult rats in short term culture …

The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons

PA Koplas, RL Rosenberg, GS Oxford - Journal of Neuroscience, 1997 - Soc Neuroscience
Capsaicin (Cap) is a pungent extract of the Capsicum pepper family, which activates
nociceptive primary sensory neurons. Inward current and membrane potential responses of …

[HTML][HTML] Multiple capsaicin-induced currents in isolated rat sensory neurons

M Petersen, RH Lamotte, A Klusch, KD Kniffki - Neuroscience, 1996 - Elsevier
The response to capsaicin in functional assays suggests multiple sites of capsaicin action.
This hypothesis is supported by the results of the present patch-clamp study of isolated …

Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel

J Jung, SW Hwang, J Kwak, SY Lee… - Journal of …, 1999 - Soc Neuroscience
Capsaicin (CAP) excites small sensory neurons, causing pain, neurogenic inflammation,
and other visceral reflexes. These effects have been proposed to be the result of CAP …

Capsaicin causes prolonged inhibition of voltage-activated calcium currents in adult rat dorsal root ganglion neurons in culture

RJ Docherty, B Robertson, S Bevan - Neuroscience, 1991 - Elsevier
The effect of capsaicin on voltage-activated calcium currents was investigated in
voltageclamped somata of cultured adult rat dorsal root ganglion neurons. About half the …

Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats

RJ Docherty, JC Yeats, S Bevan, H Boddeke - Pflügers Archiv, 1996 - Springer
Capsaicin activates a non-specific cation conductance in mammalian sensory neurones. If
capsaicin is applied continuously or repeatedly then there is a progressive decline in …

Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons

U Oh, SW Hwang, D Kim - Journal of Neuroscience, 1996 - Soc Neuroscience
Capsaicin (CAP), a neurotoxin, has been reported to activate a nonselective cation current
in dorsal root ganglion (DRG) neurons. In this paper, we identify and describe the properties …

A rapid capsaicin-activated current in rat trigeminal ganglion neurons.

L Liu, SA Simon - Proceedings of the National Academy of …, 1994 - National Acad Sciences
A subpopulation of pain fibers are activated by capsaicin, the ingredient in red peppers that
produces a burning sensation when eaten or placed on skin. Previous studies on dorsal root …

Capsaicin-induced membrane currents in cultured sensory neurons of the rat.

V Vlachová, L Vyklický - Physiological Research, 1993 - europepmc.org
Membrane currents induced by capsaicin (CAPS) in cultured sensory neurons from 1-to 2-
day-old rats were studied. Responses to CAPS (10 microM) exceeding 1 nA at-50 mV were …