As an exclusively human pathogen, Streptococcus pyogenes (the group A streptococcus
[GAS]) has specifically adapted to evade host innate immunity and survive in multiple tissue …

The ability of a pathogen to metabolically adapt to the local environment for optimal
expression of virulence determinants is a continued area of research. Orthologs of the …

Neutrophils are a critical component of human innate host defense and efficiently kill the
vast majority of invading microorganisms. However, bacterial pathogens such as group A …

Streptococcus pyogenes (group A streptococci; GAS) is an exclusively human pathogen. It
causes a variety of suppurative and non-suppurative diseases in people of all ages …

The ability of a pathogen to evade neutrophil phagocytic killing mechanisms is critically
important for dissemination and establishment of a systemic infection. Understanding how …

The group A streptococcus (GAS) is a strict human pathogen responsible for a wide
spectrum of diseases. Although GAS genome sequences are available, functional genomic …

The molecular basis for bacterial responses to host signals during natural infections is
poorly understood. The gram-positive bacterial pathogen group A Streptococcus (GAS) …

To colonize and cause disease at distinct anatomical sites, bacterial pathogens must tailor
gene expression in a microenvironment-specific manner. The molecular mechanisms that …

Coordinate regulation of virulence factors by the group A streptococcus (GAS) Streptococcus
pyogenes is important in this pathogen's ability to cause disease. To further elucidate the …

Group A Streptococcus (GAS) evades polymorphonuclear leukocyte (PMN) phagocytosis
and killing to cause human disease, including pharyngitis and necrotizing fasciitis (flesh …