Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesis
The MYC oncogene has been implicated in the regulation of up to thousands of genes
involved in many cellular programs including proliferation, growth, differentiation, self …
involved in many cellular programs including proliferation, growth, differentiation, self …
Reversible Kinetic Analysis of Myc Targets In vivo Provides Novel Insights into Myc-Mediated Tumorigenesis
ER Lawlor, L Soucek, L Brown-Swigart, K Shchors… - Cancer research, 2006 - AACR
Deregulated expression of the Myc transcription factor is a frequent causal mutation in
human cancer. Thousands of putative Myc target genes have been identified in in vitro …
human cancer. Thousands of putative Myc target genes have been identified in in vitro …
Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance
MYC overexpression has been implicated in the pathogenesis of most types of human
cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene …
cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene …
A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors
O Schuldiner, N Benvenisty - Oncogene, 2001 - nature.com
MYC proto-oncogenes play a major role in various types of human tumors. The products of
these genes are transcription factors that bind to specific sequences and activate the …
these genes are transcription factors that bind to specific sequences and activate the …
Identifying genes regulated in a Myc-dependent manner
JD Watson, SK Oster, M Shago, F Khosravi… - Journal of Biological …, 2002 - ASBMB
The c-myc proto-oncogene can direct a diverse array of biological activities, including cell
cycle progression, apoptosis, and differentiation. It is believed that Myc can affect this wide …
cycle progression, apoptosis, and differentiation. It is believed that Myc can affect this wide …
A large scale genetic analysis of c-Myc-regulated gene expression patterns* 210
BC O'Connell, AF Cheung, CP Simkevich… - Journal of Biological …, 2003 - ASBMB
The myc proto-oncogenes encode transcriptional regulators whose inappropriate
expression is correlated with a wide array of human malignancies. Up-regulation of Myc …
expression is correlated with a wide array of human malignancies. Up-regulation of Myc …
Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters
CS Yap, AL Peterson, G Castellani, JM Sedivy… - Cell Cycle, 2011 - Taylor & Francis
Mammalian c-Myc is a member of a small family of three related proto-oncogenic
transcription factors. c-Myc has an unusually broad array of regulatory functions, which …
transcription factors. c-Myc has an unusually broad array of regulatory functions, which …
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
HA Coller, C Grandori, P Tamayo… - Proceedings of the …, 2000 - National Acad Sciences
MYC affects normal and neoplastic cell proliferation by altering gene expression, but the
precise pathways remain unclear. We used oligonucleotide microarray analysis of 6,416 …
precise pathways remain unclear. We used oligonucleotide microarray analysis of 6,416 …
The transcriptional program of a human B cell line in response to Myc
M Schuhmacher, F Kohlhuber, M Hölzel… - Nucleic acids …, 2001 - academic.oup.com
The proto-oncogene c-myc (myc) encodes a transcription factor (Myc) that promotes growth,
proliferation and apoptosis. Myc has been suggested to induce these effects by …
proliferation and apoptosis. Myc has been suggested to induce these effects by …
Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation
The functions of key oncogenic transcription factors independent of context have not been
fully delineated despite our richer understanding of the genetic alterations in human …
fully delineated despite our richer understanding of the genetic alterations in human …