An important determinant of [H+] in the environment of the central chemoreceptors is
cerebral blood flow. Accordingly we hypothesized that a reduction of brain perfusion or a …

Cerebrovascular reactivity to changes in the partial pressure of arterial carbon dioxide (P)
via limiting changes in brain [H+] modulates ventilatory control. It remains unclear, however …

This study investigated the hypothesis that hypercapnia in some chronic obstructive
pulmonary disease (COPD) patients may be related to a high cerebrovascular response to …

This study examined the effect of high, normal, and uncontrolled end-tidal Pco2 (PetCO2) on
the ventilatory, peak cerebral blood flow velocity (V̄ p), and mean arterial blood pressure …

The respiratory and cerebrovascular reactivity to changes in arterial Pco2 () is an important
mechanism that maintains CO2 or pH homeostasis in the brain. It remains unclear, however …

New Findings What is the topic of this review? Cerebrovascular reactivity to CO2, which is a
principal factor in determining ventilatory responses to CO2 through the role reactivity plays …

Findings from studies of the effects of aging on the human respiratory controller are
equivocal. This study assessed the ventilatory response to CO2 in hyperoxia and hypoxia in …

New Findings What is the central question of this study? In acute hypoxia, the reduction in
arterial CO2 tension due to the hypoxic ventilatory response (respiratory chemoreflex) …

Key points Anterior and posterior cerebral circulations have differential reactivity to changes
in arterial blood gases, but the implications for the chemoreflex control of breathing are …

Cerebral blood flow (CBF) and its distribution are highly sensitive to changes in the partial
pressure of arterial CO2 (PaCO2). This physiological response, termed cerebrovascular …