We hypothesized that patients with obstructive sleep apnea (OSA) have a different awake
ventilatory response to carbon dioxide above and below eupnea compared with normal …

The time course of the decrease in ventilation immediately after 1 min of voluntary isocapnic
hyperventilation was studied in eight healthy subjects. The hyperventilation tests were done …

The responses of common carotid blood flow (CCF), pressure (BP), and resistance (R) to
variations in respiratory gases were compared during waking periods in 10 sleep apnea …

Although it is known that the vasculatures of the brain and the forearm are sensitive to
changes in arterial Pco2, previous investigations have not made direct comparisons of the …

Steplike end-tidal hypoxic drives (Petcoco2,= 53 Torr) lasting for 5 min were generated in a
group of normal subjects and a group of carotid body-resected subjects when end-tidal CO2 …

After voluntary hyperventilation, normal humans do not develop a significant ventilatory
depression despite low arterial CO2 tension, a phenomenon attributed to activation of a …

Cerebral blood flow (CBF) was measured by 133Xe clearance simultaneously with the
velocity of blood flow through the left middle cerebral artery (MCA) over a wide range of …

Although the cerebrovasculature is known to be exquisitely sensitive to CO2, there is no
consensus on whether the sympathetic nervous system plays a role in regulating …

The relationship between CO2 and ventilatory response to sustained hypoxia was examined
in nine normal young adults. At three different levels of end-tidal partial pressure of CO2 …

Hypoxia increases the ventilatory response to exercise, which leads to hyperventilation-
induced hypocapnia and subsequent reduction in cerebral blood flow (CBF). We studied the …