Sepsis as a disease has received renewed interests since recent publications of a revised
clinical definition and crucial clinical trials showing the benefits of early goal-directed …

Despite numerous advances in medicine, sepsis remains an unconquered challenge.
Although outcomes have improved slightly over decades, the unacceptably high mortality …

This book is designed to provide a comprehensive and state-of-the-art resource for
clinicians who care for patients with sepsis and research scientist alike,. Patients with severe …

Sepsis and septic shock are a continuum of disease resulting from a complex host response
to infection. They are major health issues in the United States, causing significant financial …

An estimated 750,000 cases of severe sepsis occur annually in the United States, and the
mortality rate is about 30%. As a condition that disproportionately affects the elderly and is …

Severe sepsis and septic shock are as common and lethal as other acute life-threatening
conditions that emergency physicians routinely confront such as acute myocardial infarction …

Despite several advancements in care over the last few decades, sepsis continues to carry a
high morbidity and mortality burden in the United States. With its varied presentations, cases …

Sepsis is associated with significant morbidity and mortality if not promptly recognized and
treated. Since the development of early goal-directed therapy, mortality rates have …

Introduction: Optimal management of severe sepsis in the ED has evolved rapidly. The
purpose of these guidelines is to review key management principles for Canadian …

Increased attention has focused recently on the acute management of severe sepsis and
septic shock, conditions that represent the end-stage systemic deterioration of overwhelming …