Gemcitabine resistance in pancreatic ductal carcinoma cell lines stems from reprogramming of energy metabolism
R Fujiwara-Tani, T Sasaki, T Takagi, S Mori… - International Journal of …, 2022 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis because it is
often detected at an advanced stage, and drug resistance interferes with treatment …
often detected at an advanced stage, and drug resistance interferes with treatment …
Insights into gemcitabine resistance and the potential for therapeutic monitoring
Introduction Gemcitabine is an important component of pancreatic cancer clinical
management. Unfortunately, acquired gemcitabine resistance is widespread and there are …
management. Unfortunately, acquired gemcitabine resistance is widespread and there are …
Overcoming drug resistance in pancreatic cancer
J Long, Y Zhang, X Yu, J Yang, DG LeBrun… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Pancreatic cancer has the worst survival rate of all cancers. The current
standard care for metastatic pancreatic cancer is gemcitabine, however, the success of this …
standard care for metastatic pancreatic cancer is gemcitabine, however, the success of this …
Is the resistance of gemcitabine for pancreatic cancer settled only by overexpression of deoxycytidine kinase?
N Funamizu, A Okamoto, Y Kamata… - Oncology …, 2010 - spandidos-publications.com
The prognosis of pancreatic cancer remains poor, and the standard first-line chemotherapy
with gemcitabine (GEM) has a response rate of less than 20%. Since expression of …
with gemcitabine (GEM) has a response rate of less than 20%. Since expression of …
[HTML][HTML] Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance
M Capula, M Perán, G Xu, V Donati, D Yee… - Drug Resistance …, 2022 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) has one of the highest incidence/death ratios
among all neoplasms due to its late diagnosis and dominant chemoresistance. Most PDAC …
among all neoplasms due to its late diagnosis and dominant chemoresistance. Most PDAC …
Identification of chemoresistance‐related mRNAs based on gemcitabine‐resistant pancreatic cancer cell lines
J Zhou, L Zhang, H Zheng, W Ge, Y Huang… - Cancer …, 2020 - Wiley Online Library
Gemcitabine (GEM) alone and GEM‐based chemotherapy are the preferred regimens for
treating advanced unresectable and metastatic pancreatic cancer (PC). However, these …
treating advanced unresectable and metastatic pancreatic cancer (PC). However, these …
Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA-and MCT4-mediated enhanced glycolysis
M Amrutkar, K Berg, A Balto, MG Skilbrei… - Cancer cell …, 2023 - Springer
Background Profound resistance to chemotherapy remains a major challenge in achieving
better clinical outcomes for patients with pancreatic ductal adenocarcinoma (PDAC). Recent …
better clinical outcomes for patients with pancreatic ductal adenocarcinoma (PDAC). Recent …
Mechanisms underlying gemcitabine resistance in pancreatic cancer and sensitisation by the iMiD™ lenalidomide
RA Fryer, B Barlett, C Galustian… - Anticancer …, 2011 - ar.iiarjournals.org
Gemcitabine is currently the leading therapeutic for pancreatic cancer treatment, despite
growing resistance. Studying the mechanisms that underlie gemcitabine resistance and …
growing resistance. Studying the mechanisms that underlie gemcitabine resistance and …
Deoxycytidine release from pancreatic stellate cells promotes gemcitabine resistance
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths in the
United States. The deoxynucleoside analogue gemcitabine is among the most effective …
United States. The deoxynucleoside analogue gemcitabine is among the most effective …
Drug resistance in pancreatic cancer: New player caught in act
G Capurso, C Sette - EBioMedicine, 2019 - thelancet.com
Most human cancers display high levels of heterogeneity, a feature that often impacts
negatively on the response to treatments. Indeed, while radio and/or chemotherapy initially …
negatively on the response to treatments. Indeed, while radio and/or chemotherapy initially …