Chronic inflammation is a leading cause of neoplastic transformation in many human
cancers and especially in colon cancer (CC), in part due to tumour promotion by nitric oxide …

Background Nitric oxide (NO) has been highlighted as an important agent in cancer-related
events. Although the inducible nitric oxide synthase (iNOS) isoform has received most …

Metastasis is the major cause of cancer-related death in patients with colorectal cancer.
Although inducible nitric oxide synthase (iNOS) is a crucial regulator of cancer development …

Colorectal cancer (CRC) is one of the most lethal malignancies worldwide and CRC therapy
remains unsatisfactory. In recent decades, nitric oxide (NO)—a free-radical gas—plus its …

Inducible nitric oxide (NO) synthase (iNOS) appears to be a marker of tumor progression in
colon carcinogenesis. Here we investigated effects of NO on selected chemokines that …

In colorectal cancer (CRC), cancer stem cells (CSC s) have been hypothesized to mediate
cell survival and chemoresistance. Previous studies from our laboratory described a role for …

The colon epithelium is a primary point of interaction with the microbiome and is
regenerated by a few rapidly cycling colonic stem cells (CSCs). CSC self-renewal and …

Background & Aims: Nitric oxide (NO) is an important mediator of intestinal inflammation.
Inducible NO synthase (iNOS) is the main source of NO in inflammation. Because iNOS is …

Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation;
however, the mechanisms that link inflammation to CRC development and progression are …

Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …