Rationale: Transcriptional profiling can detect subclinical heart disease and provide insight
into disease etiology and functional status. Current microarray-based methods are …

Background: The human heart requires a complex ensemble of specialized cell types to
perform its essential function. A greater knowledge of the intricate cellular milieu of the heart …

OBJECTIVES: The knowledge of chamber-specific gene expression in human atrial and
ventricular myocardium is essential for the understanding of myocardial function and the …

Rationale: Accurate and comprehensive de novo transcriptome profiling in heart is a central
issue to better understand cardiac physiology and diseases. Although significant progress …

To obtain region-and disease-specific transcription profiles of human myocardial tissue, we
explored mRNA expression from all four chambers of eight explanted failing [idiopathic …

Clinically translatable large animal models have become indispensable for cardiovascular
research, clinically relevant proof of concept studies and for novel therapeutic interventions …

Dramatic progress has been made in the technologies available to assess global alterations
in mRNA levels in both clinical and research samples. Through commercial services and …

Identifying key genes that regulate the complex diseases of the cardiovascular system can
be greatly facilitated with the use of microarrays. In an effort to obtain a global portrait of …

With the emergence of microarray technology, it is now possible to simultaneously assess
the expression of tens of thousands of gene transcripts, providing a resolution and precision …

Background—Microarrays and RNA sequencing are widely used to profile transcriptome
remodeling during myocardial ischemia. However, the steady-state RNA analysis lacks in …