Genomic sequencing has implicated large numbers of genes and de novo mutations as
potential disease risk factors. A high throughput in vivo model system is needed to validate …

A deeper knowledge of the dynamic transcriptional activity of promoters and enhancers is
needed to improve mechanistic understanding of the pathogenesis of heart failure and heart …

MicroRNA has been shown to be essential for correct cardiovascular development and
physiology in a number of recent reports. Studies have also started to characterize the link …

The regulatory networks governing gene expression in cardiomyocytes are under intense
investigation, not least because dysregulation of the gene programme has a fundamental …

A traditional approach to investigate the genetic basis of complex diseases is to identify
genes with a global change in expression between diseased and healthy individuals …

Cardiovascular disease is the most important cause of morbidity and mortality in developed
countries, causing twice as many deaths as cancer in the USA. The major cardiovascular …

High throughput sequencing technologies have become essential in studies on genomics,
epigenomics, and transcriptomics. Although sequencing information has traditionally been …

Heart development is a continuous process involving significant remodeling during
embryogenesis and neonatal stages. To date, several groups have used single-cell …

A central dogma in cardiac biology is that the postnatal heart adopts a fetal-like
transcriptional state in response to stress. 1 Consequently, the so-called “fetal gene …

Background—Normal myocardial development and the tissue response to cardiac stress are
accompanied by marked changes in gene expression; however, the extent of these changes …