Androgen receptor and MYC equilibration centralizes on developmental super-enhancer
Androgen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of
multiple genes including MYC, and supraphysiological androgen is effective in some …
multiple genes including MYC, and supraphysiological androgen is effective in some …
Androgen receptor-mediated transcription in prostate cancer
Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate
cancer (PCa) growth and differentiation. This process involves a complex interplay of …
cancer (PCa) growth and differentiation. This process involves a complex interplay of …
Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential
J Kneppers, TM Severson, JC Siefert, P Schol… - Nature …, 2022 - nature.com
Androgen receptor (AR) drives prostate cancer (PCa) development and progression. AR
chromatin binding profiles are highly plastic and form recurrent programmatic changes that …
chromatin binding profiles are highly plastic and form recurrent programmatic changes that …
MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets
Abstract c-MYC (MYC) is a major driver of prostate cancer tumorigenesis and progression.
Although MYC is overexpressed in both early and metastatic disease and associated with …
Although MYC is overexpressed in both early and metastatic disease and associated with …
Androgen receptor promotes ligand-independent prostate cancer progression through c-Myc upregulation
L Gao, J Schwartzman, A Gibbs, R Lisac… - PloS one, 2013 - journals.plos.org
The androgen receptor (AR) is the principal therapeutic target in prostate cancer. For the
past 70 years, androgen deprivation therapy (ADT) has been the major therapeutic focus …
past 70 years, androgen deprivation therapy (ADT) has been the major therapeutic focus …
Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells
L Jia, HC Shen, M Wantroba, O Khalid… - … and cellular biology, 2006 - Am Soc Microbiol
Prostate cancers (PCas) become resistant to hormone withdrawal through increased
androgen receptor (AR) signaling. Here we show increased AR-mediated transcription …
androgen receptor (AR) signaling. Here we show increased AR-mediated transcription …
A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer
Standard treatment for metastatic prostate cancer (CaP) prevents ligand-activation of
androgen receptor (AR). Despite initial remission, CaP progresses while relying on AR. AR …
androgen receptor (AR). Despite initial remission, CaP progresses while relying on AR. AR …
A transcriptional repressor co‐regulatory network governing androgen response in prostate cancers
Transcriptional corepressors are frequently aberrantly over‐expressed in prostate cancers.
However, their crosstalk with the Androgen receptor (AR), a key player in prostate cancer …
However, their crosstalk with the Androgen receptor (AR), a key player in prostate cancer …
[HTML][HTML] Androgen receptor genomic regulation
The transcriptional activity of the androgen receptor (AR) is not only critical for the normal
development and function of the prostate but also pivotal to the onset and progression of …
development and function of the prostate but also pivotal to the onset and progression of …
[PDF][PDF] Regulation of tumor cell plasticity by the androgen receptor in prostate cancer
Prostate cancer (PCa) has become the most common form of cancer in men in the
developed world, and it ranks second in cancer-related deaths. Men that succumb to PCa …
developed world, and it ranks second in cancer-related deaths. Men that succumb to PCa …