Various preclinical models have been developed to clarify the pathophysiology of prostate
cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by …

Prostate cancer remains a lethal disease. Preclinical cancer models that accurately
represent the tumors of the patients they are intended to help are necessary to test potential …

Background While it has been challenging to establish prostate cancer patient‐derived
xenografts (PDXs), with a take rate of 10‐40% and long latency time, multiple groups …

Prostate cancer continues to be a major cause of morbidity and mortality in men around the
world. The field of prostate cancer research continues to be hindered by the lack of relevant …

BACKGROUND Metastatic prostate cancer is a common and lethal disease for which there
are no therapies that produce cures or long‐term durable remissions. Clinically relevant …

New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …

Simple Summary The molecular progression of prostate cancer is complex and elusive.
Biological research relies heavily on in vitro and in vivo models that can be used to examine …

Prostate cancer continues to be the second leading cancer related death among men. In
order to more fully develop effective prevention and intervention strategies for this prevalent …

The lack of effective therapies for bone metastatic prostate cancer (PCa) underscores the
need for accurate models of the disease to enable the discovery of new therapeutic targets …

Animal models, particularly mouse models, play a central role in the study of the etiology,
prevention, and treatment of human prostate cancer. While tissue culture models are …