Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing

DW Eyre, ML Cule, DJ Wilson, D Griffiths… - … England Journal of …, 2013 - Mass Medical Soc
Background It has been thought that Clostridium difficile infection is transmitted
predominantly within health care settings. However, endemic spread has hampered …

Clostridium difficile: Investigating Transmission Patterns Between Infected and Colonized Patients Using Whole Genome Sequencing

LY Kong, DW Eyre, J Corbeil… - Clinical Infectious …, 2019 - academic.oup.com
Background Whole genome sequencing (WGS) studies can enhance our understanding of
the role of patients with asymptomatic Clostridium difficile colonization in transmission …

[HTML][HTML] Asymptomatic Clostridium difficile Colonisation and Onward Transmission

DW Eyre, D Griffiths, A Vaughan, T Golubchik… - PloS one, 2013 - journals.plos.org
Introduction Combined genotyping/whole genome sequencing and epidemiological data
suggest that in endemic settings only a minority of Clostridium difficile infection, CDI, is …

Two Distinct Patterns of Clostridium difficile Diversity Across Europe Indicating Contrasting Routes of Spread

DW Eyre, KA Davies, G Davis… - Clinical Infectious …, 2018 - academic.oup.com
Abstract Background Rates of Clostridium difficile infection vary widely across Europe, as do
prevalent ribotypes. The extent of Europe-wide diversity within each ribotype, however, is …

Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence

N Kumar, F Miyajima, M He, P Roberts… - Clinical Infectious …, 2016 - academic.oup.com
Abstract Background. Accurate tracking of Clostridium difficile transmission within healthcare
settings is key to its containment but is hindered by the lack of discriminatory power of …

Molecular epidemiology of endemic Clostridium difficile infection

WN Fawley, MH Wilcox - Epidemiology & Infection, 2001 - cambridge.org
This is the first study to provide a comprehensive insight into the molecular epidemiology of
endemic Clostridium difficile and particularly that associated with a recently recognized …

Clostridium difficile infection: epidemiology, diagnosis and understanding transmission

JSH Martin, TM Monaghan, MH Wilcox - … reviews Gastroenterology & …, 2016 - nature.com
Clostridium difficile infection (CDI) continues to affect patients in hospitals and communities
worldwide. The spectrum of clinical disease ranges from mild diarrhoea to toxic megacolon …

[HTML][HTML] Microevolutionary analysis of Clostridium difficile genomes to investigate transmission

X Didelot, DW Eyre, M Cule, CLC Ip, MA Ansari… - Genome biology, 2012 - Springer
Abstract Background The control of Clostridium difficile infection is a major international
healthcare priority, hindered by a limited understanding of transmission epidemiology for …

Molecular epidemiology of Clostridium difficile infection in a major chinese hospital: an underrecognized problem in Asia?

PM Hawkey, C Marriott, WE Liu, ZJ Jian… - Journal of clinical …, 2013 - Am Soc Microbiol
Clostridium difficile infection is almost unrecognized in mainland China. We have
undertaken a study in a large Chinese teaching hospital in Changsha, Hunan, China, to …

[HTML][HTML] Macro and Micro Diversity of Clostridium difficile Isolates from Diverse Sources and Geographical Locations

RA Stabler, LF Dawson, E Valiente, MD Cairns… - PloS one, 2012 - journals.plos.org
Clostridium difficile has emerged rapidly as the leading cause of antibiotic-associated
diarrheal disease, with the temporal and geographical appearance of dominant PCR …