Purpose To probe the variation of alveolar size in healthy lung tissue as a function of posture
using diffusion‐weighted helium‐3 hyperpolarized gas imaging. Materials and Methods …

Although the apparent diffusion coefficient (ADC) of 3He has been measured in the human
lung [1, 2, 3], no studies have determined the reproducibility of ADC values. Since the ADC …

Magnetic resonance imaging of the apparent diffusion coefficient (ADC) of hyperpolarized
Helium-3 is a new technique for probing pulmonary microstructure in vivo. The aim of this …

Purpose To measure the apparent diffusion coefficient (ADC) of hyperpolarized (HP) 3He
gas using diffusion weighted MRI in healthy volunteers and patients with emphysema and …

Hyperpolarised gases have been most recently used in magnetic resonance imaging to
demonstrate new image-derived pulmonary function parameters. One of these parameters is …

Rationale: The apparent diffusion coefficient of hyperpolarized 3He in the lungs has been
shown to correlate directly in animal models with the peripheral airspace size and can detect …

The study of lung emphysema dates back to the beginning of the 17th century. Nevertheless,
a number of important questions remain unanswered because a quantitative localized …

MRI-based study of 3He gas diffusion in lungs may provide important information on lung
microstructure. Lung acinar airways can be described in terms of cylinders covered with …

Functional MRI of the lungs with hyperpolarized helium provides an index of apparent
diffusion measured over several seconds (ADCsec) that is only 2% of its free diffusion in air …

PURPOSE: To quantitatively evaluate hyperpolarized helium 3 (3He) diffusion magnetic
resonance (MR) images of the lung in patients with emphysema and to determine whether …