Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …

The MYC proto-oncogene is frequently deregulated in human cancers, activating genetic
programs that orchestrate biological processes to promote growth and proliferation. Altered …

MYC is a multifunctional transcription factor that is deregulated in many human cancers.
MYC impacts a collaborative genetic program that orchestrates cell proliferation …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

The MYC proto-oncogene is frequently activated in human cancers through a variety of
mechanisms. Its deregulated expression, unconstrained by inactivation of key checkpoints …

Studies from many laboratories document that the MYC oncogene produces a pleiotropic
transcription factor, Myc, which influences genes driven by all three RNA polymerases to …

Although cancers have altered glucose metabolism, termed the Warburg effect, which
describes the increased uptake and conversion of glucose to lactate by cancer cells under …

Transcription factors of the MYC family are deregulated in the majority of all human cancers.
Oncogenic levels of MYC reprogram cellular metabolism, a hallmark of cancer development …

Simple Summary In the last decade, metabolic reprogramming has emerged as a driving
characteristic of cancer cells. The MYC oncogene, a transcription factor, has become of …

MYCN amplification drives the development of neuronal cancers in children and adults.
Given the challenge in therapeutically targeting MYCN directly, we searched for MYCN …