Higher oxidant stress capacity could promote invasion and metastasis. A previous study
showed hepatocellular carcinoma (HCC) expressed more Nrf2 than para-carcinoma tissue …

Background Nuclear factor E2-related factor 2 (Nrf2 or NFE2L2) is abundantly expressed in
cancer cells and relates to proliferation, invasion, and chemoresistance. Our early …

Nuclear factor erythroid-2-related factor 2 (Nrf2), a master transcription factor in the
antioxidant response, has been found to be ubiquitously expressed in various cancer cells …

Reactive oxygen species (ROS) is excessively generated in tumors creating an oxidative
stress in tumor microenvironment. We investigated hepatic expression of nuclear factor …

Cancer is a common comorbidity of diabetic patients; however, little is known about the
effects that antidiabetic drugs have on tumors. We discovered that common classes of drugs …

Hepatocellular carcinoma (HCC) chemoresistance, which is regarded as a kind of stress
management reaction to chemotherapy drugs, severely hinders the therapy outcomes of …

Aims: High constitutive expression of Nrf2 has been found in many types of cancers, and this
high level of Nrf2 also favors resistance to drugs and radiation. Here we investigate how …

Nuclear factor erythroid-2-related factor 2 (nrf2) is a critical cell protector by inducing phase
two detoxifying and anti-oxidant enzymes in normal cells. But recently, numerous evidence …

The liver executes versatile functions and is the chief organ for metabolism of
toxicants/xenobiotics. Hepatocellular carcinoma (HCC) is the most common primary liver …

NRF2 is a nuclear transcription factor activated in response to oxidative stress and related
with metabolizing of xenotoxic materials and ABC transporter mediated drug resistance. We …