The employment of liquid chromatography‐mass spectrometry (LC‐MS) untargeted and
targeted metabolomics has led to the discovery of novel biomarkers and improved the …

Metabolomics is emerging as a promising systems biology approach for many research
fields including functional genomics, disease diagnosis, nutrition science, and drug …

Metabolomics has advanced significantly in the past 10 years with important developments
related to hardware, software and methodologies and an increasing complexity of …

Targeted metabolite assays that measure tens or hundreds of pre-selected metabolites,
typically using liquid chromatography–mass spectrometry, are increasingly being developed …

In metabolomics, a large number of small molecules can be detected in a single run.
However, metabolomic data do not include the absolute concentrations of each metabolite …

Recently, metabolomics—the study of metabolite profiles within biological samples—has
found a wide range of applications. This chapter describes the different techniques available …

In recent years, metabolomics has emerged as a pivotal approach for the holistic analysis of
metabolites in biological systems. The rapid progress in analytical equipment, coupled to the …

Rationale The metabolite profiling of a NIST plasma Standard Reference Material (SRM
1950) on different liquid chromatography/mass spectrometry (LC/MS) platforms showed …

Untargeted metabolic profiling has generated large activity in the field of clinical biomarker
discovery. Yet, no clinically approved metabolite biomarkers have emerged with failure in …

BACKGROUND The metabolome of any given biological system contains a diverse range of
low molecular weight molecules (metabolites), whose abundances can be affected by the …