The complaint of excessive daytime sleepiness (EDS), commonly encountered in clinical
practice, may arise from a variety of psychiatric disorders, most importantly depression. Even …

It has been established that 4.4 to 20% of the general population suffers from a major
depressive disorder (MDD), which is frequently associated with a dysregulation of normal …

Major depressive disorder (MDD) remains the most prevalent mental disorder and a leading
cause of disability, affecting approximately 100 million adults worldwide. The disorder is …

Objective The aim of this article is to review progress in understanding the mechanisms that
underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of …

Since ancient times it is known that melancholia and sleep disturbances co-occur. The
introduction of polysomnography into psychiatric research confirmed a disturbance of sleep …

Background: It is unclear whether there is an association between chronotype and
nonremission of depression, and whether the association is related to the confounding effect …

Evidence for the importance of sleep in the mood disorders has mushroomed over the past
decade. Among adolescents and adults with a mood disorder, sleep disturbance is a risk …

Patients with depression often suffer from sleep disorders and non-sleep circadian
disorders. However, whether they precede and predict subsequent depression is unclear …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

Objective As part of a series of papers examining chronobiology ['Getting depression clinical
guidelines right: time for change?'Kuiper et al. Acta Psychiatr Scand 2013; 128 (Suppl. 444) …