Long term administration of an opioid drug for chronic nonmalignant pain continues to be
controversial, but is no longer uniformly rejected by pain specialists. This is true despite …

In this issue, pain experts on opioid abuse and diversion from academia, the industry and
US government agencies who participated in a Tufts Health Care Institute-supported …

While methadone has been available for over 50 years, its use in opiate dependence has
overshadowed its use as an analgesic. Within the last 10-15 years, though, methadone has …

Methadone is used for the treatment of opioid addiction and for treatment of chronic pain.
The safety of methadone has been called into question by data indicating a large increase in …

A patient was treated for several years with high doses of opioids for malignant pain. During
a recent hospitalization, the patient's pain remained uncontrolled despite escalating doses …

BACKGROUND: Both clinicians and researchers have expressed doubt that opiate
dependent patients with significant pain can be effectively treated in methadone …

Abstract The World Health Organization recommends a step-by-step approach to the
management of chronic cancer pain, called the analgesic ladder. Traditionally, morphine …

Methadone is a synthetic opiate receptor agonist that has been available for more than 40
years. Although its main use has been in the maintenance treatment of opioid addicts, it has …

Questions from patients about pain conditions and analgesic pharmacotherapy and
responses from authors are presented to help educate patients and make them more …

To the Editor: Methadone has an important role in the management of severe chronic pain,
whether from cancer or other causes. Patients taking methadone for pain in situations such …