It is well known that the ischemia and the reperfusion processes are distinct
nonimmunological events that negatively impact graft outcome and induce delayed graft …

Avoidance of cold ischaemic preservation damage and repair of injury sustained during
warm ischaemia and organ procurement would potentially allow many livers from extended …

In recent years, there has been growing interest in normothermic machine perfusion (NMP)
as a preservation method in liver transplantation. In most countries, because of a donor …

In the past decade, the field of transplantation has witnessed the proliferation of machine
perfusion devices that hold the potential to reverse the injury caused by static cold storage …

The number of donor organs suitable for liver transplantation is restricted by cold
preservation and ischemia–reperfusion injury. We present the first patients transplanted …

Normothermic machine perfusion (NMP), in which a donor liver is maintained in a
physiological state (at 37 C and perfused with oxygenated blood containing nutrients and …

Abrupt return to normothermia has been shown a genuine factor contributing to graft
dysfunction after transplantation. This study tested the concept to mitigate reperfusion injury …

Normothermic (36-37 o C) machine perfusion (NMP) is a novel preservation method for liver
grafts and had the benefit to improve liver quality before transplantation in animal …

After extensive experimentation, outcomes of a first clinical normothermic machine perfusion
(NMP) liver trial in the United Kingdom demonstrated feasibility and clear safety, with …

The need for donor pool expansion in liver transplantation has increased utilization of grafts
from so-called extended-criteria donors. Machine perfusion technology can improve …