Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Cardiovascular diseases remain the leading cause of death worldwide in the last decade,
accompanied by immense health and economic burdens. Heart failure (HF), as the terminal …

Heart failure is a pressing public health problem with no curative treatment currently
available. The existing therapies provide symptomatic relief, but are unable to reverse …

A number of observations have shown that mitochondria are at the center of the
pathophysiology of the failing heart and mitochondrial-based oxidative stress (OS) …

The burden of heart failure (HF) in terms of health care expenditures, hospitalizations, and
mortality is substantial and growing. The failing heart has been described as “energy …

Over the past decade, mitochondria have emerged as critical integrators of energy
production, generation of reactive oxygen species (ROS), multiple cell death, and signaling …

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart
failure, and other cardiovascular diseases, as well, but no therapies are available to treat …

Mitochondrial dysfunction is considered as a crucial contributory factor in cardiac pathology.
This has highlighted the therapeutic potential of targeting mitochondria to prevent or treat …

The mitochondrion serves a critical role as a platform for energy transduction, signaling, and
cell death pathways relevant to common diseases of the myocardium such as heart failure …

Mitochondrial dysfunction has been implicated in the development of heart failure. Oxidative
metabolism in mitochondria is the main energy source of the heart, and the inability to …