Background DNA methylation is an epigenetic mechanism that has been proposed as a
possible link between genetic and environmental determinants of disease. Prior studies …

Little is known about the extent to which interactions between genetics and epigenetics may
affect the risk of complex metabolic diseases and/or their intermediary phenotypes. We …

Background Alterations in DNA methylation are demonstrated in atherosclerosis
pathogenesis. However, changing rules of global DNA methylation and hydroxymethylation …

Background Elevated adiposity is often posited by medical and public health researchers to
be a risk factor associated with cardiovascular disease, diabetes, and other diseases. These …

Epigenome-Wide Association Studies (EWAS) are furthering our knowledge of epigenetic
modifications involved in the regulation of lipids' metabolism. Furthermore, epigenetic …

BACKGROUND: Lower blood DNA methylation has been associated with atherosclerosis
and high cardiovascular risk. Mechanisms linking DNA hypomethylation to increased …

Underlying mechanisms of cardiovascular diseases (CVD) have been investigated for over
100 years and novel molecular level mechanisms in the pathophysiology are still …

Rationale: Acute coronary syndrome (ACS) is a leading cause of death worldwide. Immune
functions play a vital role in ACS development; however, whether epigenetic modulation …

Epidemiological studies have demonstrated that genetic, environmental, behavioral, and
clinical factors contribute to cardiovascular disease development. How these risk factors …

Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …