Diabetic keratopathy (DK) is an important diabetic complication at the ocular surface.
Chronic low-grade inflammation mediated by the NLRP3 inflammasome promotes …

We evaluated the role of NLR family pyrin domain containing 3 (NLRP3) inflammasome in
sterile corneal inflammation caused by lipopolysaccharide (LPS) or alkali burns in C57BL6 …

Objective and design Chronic low-grade inflammation occurs in diabetic retinopathy (DR),
but the underlying mechanism (s) remains (remain) unclear. NLRP3 inflammasome …

In studies on dry eye (DE) disease, an association has been identified between tear film
hyperosmolarity and inflammation severity elicited through receptor-induced increases in …

Diabetic Retinopathy (DR) is an insidious neurovascular disorder secondary to chronic
glycemic dysregulation in elderly diabetic patients. In the later stages of DR, the disease …

Advanced Glycation End Products (AGEs) Induce Apoptosis of Fibroblasts by Activation of
NLRP3 Inflammasome via Reactive Oxygen Species (ROS) Signaling Pathway - PMC Back to …

Diabetic retinopathy (DR) is a retinal microvascular disease characterized by inflammatory
and angiogenic pathways. In this study, we evaluated NLRP3 inflammasome in a double …

Wound healing is a major secondary complication in type 2 diabetes, which results in
significant disability and mortality, imposing a significant clinical and social burden …

Inflamm-aging was recently affiliated with the progression of diabetic complications. Local
cellular senescence together with senescence-associated secretory phenotype (SASP) are …

Epithelial cells are involved in the regulation of innate and adaptive immunity in response to
different stresses. The purpose of this study was to investigate if alkali-injured corneal …