Here, we showed that the secretome of senescent melanoma cells drives basal melanoma
cells towards a mesenchymal phenotype, with characteristic of stems illustrated by …

Melanoma cells can enter the process of senescence, but whether they express a secretory
phenotype, as reported for other cells, is undetermined. This is of paramount importance …

Cellular senescence is a therapy endpoint in melanoma, and the senescence-associated
secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing …

Immune checkpoint blockade (ICB) therapy is a central pillar of melanoma treatment leading
to durable response rates. Important mechanisms of action of ICB therapy include …

Cellular senescence is a stress response associated with aging and disease, including
cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology …

Cellular senescence is defined as an irreversible growth arrest with the acquisition of a
distinctive secretome. The growth arrest is a potent anticancer mechanism whereas the …

Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by
various cellular stresses and is known to play a pivotal role in tumour suppression. While …

As a point of convergence for numerous oncogenic signaling pathways, STAT3 is
constitutively-activated at 50 to 90% frequency in diverse human cancers, including …

Cellular senescence in cancer development is known to have tumor‐suppressive and tumor‐
promoting roles. Recent studies have revealed numerous molecular mechanisms of …

Senescent cells promote tumor clearance by evoking an antitumor immune response.
However in Pten-null prostate tumors treated with chemotherapy, the antitumor immune …