Bone metastases are a frequent clinical problem in patients with breast, prostate, and other
cancers. Formation of these lesions is a site-specific process determined by multiple cellular …

BACKGROUND This review summarizes evidence that the formation of bone metastases is
the result of multiple synergistic cellular and molecular interactions between metastatic cells …

Background Bone metastases cause morbidity and mortality in multiple malignancies. In
addition to portending a dire prognosis, bone metastases cause bone pain, fractures …

Alterations in bone architecture and mineral metabolism are common complications of
malignancy. Cancers such as breast, prostate, and lung can affect the skeleton either …

Bone metastases are common complications of many cancers. Among the mechanisms that
set the scene for the development of bone metastases, several are shared by all forms of …

In human cancers, bone is a common site for metastasis. It is well known that metastasis is
the cause of morbidity and mortality in patients with cancer. Both breast and prostate …

The skeleton is a unique structure capable of providing support for the body. Bone
resorption and deposition are controlled in a tightly regulated balance between osteoblasts …

This authoritative survey discusses how tumor cells cause bone metastases by producing
both local and systemic factors that disrupt the balance between bone formation and bone …

Numerous pathologic events are required for a tumor cell to metastasize to bone and
develop either a lytic or blastic lesion. These events initiate in the local environment where …

The skeleton is a common destination for many cancer metastases including breast and
prostate cancer. There are many characteristics of bone that make it an ideal environment …